You can order DMC Dissolvable Microcarriers via our product page or by requesting a quote.
Over 1 billion cells in just 14 days
Our Dissolvable Microcarrier enables you to culture more cells; faster, easier, and at lower cost.
By fully dissolving during harvest, it offers gentle, high-yield cell recovery without mechanical separation. Compatible with standard cell culture reagents, it simplifies integration in your workflow, reduces downstream complexity, and improves overall efficiency.
Culture more cells with DMC Dissolvable Microcarriers
DMC is a biopolymer-based Dissolvable Microcarrier that consists of an ultra pure gelatin coated alginate microparticle. The premium gelatin from Rousselot Biomedial provides a physiological, soft cell-material interface that support a wide variety of adherent cell types, including mesenchymal stromal cells, iPSC/ESC-derived cells, VERO, CHO and HEK.
The gelatin coating promotes rapid cell attachment and growth.
With DMC Microcarriers, you can achieve faster cell growth and higher yields, reaching over 1 million cells per mL within 14 days. Their performance has been validated in a range of bioreactors, confirming robust and reproducible results.
Harvesting cells from non-dissolvable microcarriers can damage cells and results in about 50% precious cell loss. We gently and completely dissolve the microcarrier substrate to harvest the cells with an efficiency over 90%, nearly doubling your cell recovery without compromising your cell quality.
Easy integration into your workflow
DMC Dissolvable Microcarriers dissolve with standard cell culture reagents EDTA +TrypLE. You will obtain a single-cell suspension and fully dissolved biopolymers, without requiring mechanical separation steps to filter out the microcarriers and debris from your product. This will simplify the down steam processing and save cost.
In just 15 minutes after addition of EDTA and TrypLE, DMC microcarriers fully dissolve.
Validation and application
The DMC Dissolvable Microcarrier has been validated with a wide range of cell types, reactor designs and at different scales. We are working together with industry partners and users to build use cases and demonstrate its performance.
Trilineage differentiation of mesenchymal stromal cells (MSC) cultured in a 1.2L Osillaris bag reactor, generated by Fraunhofer Institute and Scinus Cell Expansion.
Frequently asked questions
For more information about DMC Dissolvable Microcarriers, check out our brochure and FAQ below, or get in contact with one of our experts.
Where can I order DMC Dissolvable microcarriers
My microcarriers do not dissolve, what should I do?
DMC Dissolvable Microcarriers consist of a alginate bead coated with crosslinked ultra pure gelatin. Both EDTA and Tryple are required to dissolve the microcarriers. If either one of these components is missing, the microcarriers might not fully dissolve.
Can DMC Dissolvable Microcarriers be autoclaved?
Yes, it is recommended to autoclave hydrated microcarriers before use. For a detailed description on how to use DMC Dissolvable Microcarriers please check out our Instruction for Use.
What is the surface area of DMC Dissolvable Microcarriers?
DMC Dissolvable Microcarriers have a surface area of 5000 cm² per gram.
What compounds remain after microcarrier dissolution?
Within 15 minutes after adding EDTA and TrypLE to dissolve your microcarriers you will obtain a single-cell suspension. Using SEC (size exclusion chromatography) we analyzed the harvest solution and observed polymer chains of alginate, short chains of gelatin, EDTA and TrypLE.
Are animal components in DMC Dissolvable Microcarriers posing a regulatory concern?
DMC Dissolvable Microcarriers show rapid cell attachment and growth. This is due to the physiological interaction of the gelatin coating with cells. We work together with Rousselot Biomedical and only use ultra pure, endotoxin controlled gelatin with excellent traceability to the farm (ISO 22442-2) and extensive documentation to ensure compliance with applicable legislation, including ISO 22442 standards and the latest EU Medical Device Regulation (EU) 2017/745 (MDR). Furthermore, it is validated for viral inactivation (ISO 22442-3).