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The advantage of monodispersity

Monodisperse or uniformly sized microparticles offers various advantages over polydisperse ones. Specifically, particle size distributions have a significant effect on their injectability,[1] flowability,[2] and release profile.[3] In other words, narrowing the size distribution of microparticles enhances the administration and delivery of the microencapsulated API.

[1] Sarmadi et al., Science Adv., 2020, 6, eabb6594.
[2] Liu et al., Int. J. Pharm., 2008, 362, 109.
[3] Berkland et al., J. Control. Release, 2002, 82, 137.

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