Scaling up 3D cell cultures with advanced microencapsulation technology

Scaling 3D cell cultures from laboratory research to clinical or industrial production is a significant challenge. In cell therapy and tissue engineering, this step remains a major obstacle. Traditional 3D culture methods face numerous issues: variable outcomes, uncontrolled cell aggregates, damage from shear stress, and, most critically, difficulties in scaling up—especially within bioreactors.

This white paper explores how microencapsulation transforms the process. By encapsulating spheroids and organoids in precise microcapsules, you achieve consistent, reproducible growth along with strong protection from shear stress. This approach merges the biological benefits of 3D aggregates with the scalable nature of suspension cultures.

Read our whitepaper to discover:

• A clear overview of current 3D cell culture techniques and their limitations.
• An in-depth examination of the science behind microencapsulation and the key design factors involved
• A detailed look at IN-AIR MICROFLUIDICS™ as a clean, gentle, and truly scalable method for microencapsulation
• Real-world examples: stem cell cultivation, functional spheroid formation, and tissue biofabrication in practice

If your work involves ATMPs, organoid systems, or scaling up cell production, this white paper offers practical insights for advancing 3D cell culture technologies from the lab into large-scale applications.